Advances in toxicological study and rapid detection of common mycotoxins in medicinal herbs
10.3867/j.issn.1000-3002.2016.12.015
- VernacularTitle:中药中常见真菌毒素毒理及快速检测技术
- Author:
Cheng ZHANG
;
Xiaowen DOU
;
Meihua YANG
- Keywords:
medicinal herbs;
mycotoxins;
toxicology;
rapid detection;
security risk
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(12):1369-1378
- CountryChina
- Language:Chinese
-
Abstract:
Mycotoxins,secondary metabolites produced by certain fungi,have become one of the most harmful factors that affect the clinical safety of medicinal herbs that probably can be contaminated by harmful toxins generated from fungi in the whole process from planting to clinical use. Therefore,more toxicological research of mycotoxins,a better knowledge of the pathogenesis and quick detection with sensitivity and accuracy will play an important role in targeted therapy of poisoning by mycotoxins and early warning . In this paper,the current status of mycotoxin contamination in medicinal herbs was ana?lyzed,and the progress of toxicological study on common contaminants was reviewed. In view of the high toxicity of toxins,the strategy of ″Prevention First″ is highly desirable. Hence,the development of rapid detection of typical mycotoxins was systematically discussed. The review was intended to provide ref?erence for ensuring clinical safe administration of medicinal herbs and for reducing the risk of mycotoxin poisoning.
