Advances toxicological research on occupational health and poison control

VernacularTitle:职业性化学中毒预防控制的毒理学研究进展
Author: Sun XIN
Keywords: chemicals; occupational poisoning; toxicity testing; risk assessment
From: Chinese Journal of Pharmacology and Toxicology 2016;30(12):1419-1423
CountryChina
Language:Chinese
Abstract: The number of chemicals that are synthesized each year has been steadily increasing. Chemicals are of immense benefits to mankind,many of which,however,have a significant negative impact on the environment as well as human health primarily due to their inherent chemistry and toxici?ty. Human exposure to numerous toxic chemicals takes place not only in the environment and but also in the workplace. Therefore,new approaches to toxicology need to developed. A milestone in this regard is the versions of the US National Research Council ″Toxicity Testing in the 21st Century:a Vision and a Strategy ″ and ″Science and Decisions:Advancing Risk Assessment ″. The versions require a radical paradigm shift in the approach to safety assessment and in the traditional procedure where animal experiments used to be the dominating technology. The future of toxicology suggests a new conceptual framework within which in vitro and in silico approaches based on human materials are used to under?stand disease pathways at multiple biological levels that are analogous to adverse outcome pathways in toxicology. This paper focuses on the many challenges and issues that need to be solved in this area.