The expression of cIAP and Caspase-7 in endometrial adenocarcinoma and its relationship with the prognosis
10.3969/j.issn.1671-8348.2016.36.021
- VernacularTitle:cIA P与Caspase-7在子宫内膜腺癌组织中的表达及其与预后的关系研究
- Author:
Yan XU
;
Tao HE
;
Hongying YUAN
- Keywords:
endometrial neoplasms;
adenocarcinoma;
inhibitor of apoptosis proteins;
Caspase 7;
immunohistochemistry
- From:
Chongqing Medicine
2016;45(36):5107-5109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cIAP and Caspase‐7 in endometrial adenocarcinoma tissue and its relation with prognosis .Methods Fifty‐five cases tissues of endometrial adenocarcinoma patients were detected by immunohistochemistry assay from the First Affiliated Hospital of Henan University of Science and Technology from 2009 to 2010 .Histological classifica‐tion ,pathological stage ,lymph node metastasis ,age and other parameters were collected ,the survival and overall survival of the tumor were followed up ,immunohistochemistry was used to observe the expression of cIAP and Caspase‐7 in paraffin sections of pathological specimens ,and the relationship between them and the parameters were analyzed .Results The expression level of cIAP and Caspase‐7 was related to the histological classification ,pathological stage and lymph node metastasis of endometrial carcinoma (P<0 .05) ,but it was not related with the age ,muscular layer infiltration(P>0 .05) .There was significant difference between the positive expression and the negative expression of cIAP and Caspase‐7(P<0 .05) .Conclusion The expression level of cIAP and Caspase‐7 in patients with endometrial carcinoma is correlated with tumor grade and overall survival ,or can be used as a prognostic indicator for endometrial cancer .
