Pharmacodynamics and pharmacokinetics of target controlled infusion of atracurium besylate on liver function of different age and gender
10.3969/j.issn.1005-1678.2016.11.056
- VernacularTitle:不同年龄、性别的肝功能不全患者靶控输注顺苯磺酸阿曲库胺的药效及药代学研究
- Author:
Xianbao HU
;
Xiang ZHENG
;
Jun ZHU
;
Guofei ZHU
- Keywords:
atracurium besylate;
liver dysfunction;
age;
gender;
pharmacodynamics;
pharmacokinetics
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):186-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of different age and gender on the efficacy and pharmacokinetics of the target controlled infusion of atracurium besylate on liver dysfunction.Methods 160 case of patients with liver dysfunction and undergoing elective general anesthesia operation were divided into four groups according to their age and gender, 40 cases in each group:group A (age≥65 years old, male), group B (age≥65 years old, female), group C (age<65 years old, male), group D (age<65 years old, female).The patients received one-time double dose ED95 atracurium besylate, pharmacodynamic indexes and pharmacokinetic parameters were compared.Results The four groups of patients with block onset time, block maintenance time, clinical duration of T25%, in vivo role time T95%, muscle relaxation recovery index were compared, the difference was not statistically significant.The preoperative and postoperative 24h, four groups of patients with liver function ( alanine aminotransferase, aspartate aminotransferase, albumin, bilirubin) and renal function ( creatinine, urea nitrogen) were compared, the difference was not statistically significant.There was no significant difference between the four groups in the plasma concentrations of the substance to be measured, the peak time, the area under the curve and the elimination half lives.Conclusion For the patients with liver dysfunction, the target controlled infusion of atracurium besylate in general anesthesia operation, gender and age were not considered.
