Tacrolimus related neurologic complication after pediatric kidney transplantation.
10.4174/jkss.2011.81.3.225
- Author:
Woo Hyung KWUN
1
Author Information
1. Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea. whkwun@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Neurotoxicity syndromes;
Tacrolimus
- MeSH:
Anterior Cerebral Artery;
Cerebral Infarction;
Constriction, Pathologic;
Headache;
Humans;
Hypertension;
Kidney;
Kidney Transplantation;
Magnetic Resonance Angiography;
Middle Cerebral Artery;
Mothers;
Neurotoxicity Syndromes;
Tacrolimus;
Transplants
- From:Journal of the Korean Surgical Society
2011;81(3):225-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently significant neurotoxicity has been reported with the use of carcineurin inhibitors. An 11-year-old-girl had undergone a transplantation of kidney from her mother. On post-operative day 12, hypertension, headache, and left motor weakness (grade I) suddenly occurred. The brain-magnetic resonance imaging and magnetic resonance angiography showed acute cerebral infarction at subcortical white matter of the right hemisphere and multiple stenoses of both anterior cerebral artery and middle cerebral artery. While stopping tacrolimus treatment, we experienced clinical and radiological improvement. So, the neurological complications of this patient seem to have been caused by the use of tacrolimus.
