Role of Warburg effect in arsenic carcinogenesis: a recent advance
10.3760/cma.j.issn.2095-4255.2017.01.017
- VernacularTitle:瓦伯格(Warburg)效应在砷致癌中作用的研究进展
- Author:
Fei LUO
;
Qizhan LIU
- Keywords:
Warburg effect;
Energy metabolism;
Aerobic glycolysis;
Arsenic poisoning;
Carcinogenesis
- From:
Chinese Journal of Endemiology
2017;36(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
The glucose metabolism pathways including glycolysis and oxidative phosphorylation in vivo.The metabolism of tumor cells depends on glycolysis,which enhances the adaptability of tumor cells to the microenvironment and promotes the proliferation of tumor cells,which is called Warburg effect.Arsenic is one of the chemical pollutants,which is widely distributed in natural environment.International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens.However,the mechanism of carcinogenesis induced by arsenic still remains obscure.Recently,researchers have found that Warburg effect plays an important role in the process of arsenic carcinogenesis.In this paper,we have reviewed the definition and function of glycolysis,its relationship with inflammation and tumorigenesis,and the role of Warburg effect in arsenic carcinogenesis.
