Meta analysis on intravenous antioxidants therapy in the treatment of moderately severe and severe acute pancreatitis
10.3760/cma.j.issn.1674-1935.2017.01.007
- VernacularTitle:静脉抗氧化剂治疗对中度重症和重症急性胰腺炎患者预后影响的Meta分析
- Author:
Wenwu SUN
;
Jinlong WANG
;
Qinlong SUN
;
Enqiang MAO
- Keywords:
Pancreatitis,acute necrotizing;
Antioxidants;
Infusions,intravenous;
Prognosis;
Meta-analysis
- From:
Chinese Journal of Pancreatology
2017;17(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of intravenous antioxidants therapy in treating moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP).Methods Pubmed,Embase,Cochrane library and CNKI databases for all randomized control trials published before March 18st,2016 manually was searched by computer.Data on AP associated mortality and length of stay (LOS) were collected.The quality of the trials included was assessed by the Cochrane systematic review method.Results Fifteen trials with data of 620 patients were eligible for final inclusion.Among the 15 trials,detailed randomization for grouping was clearly described in 5 studies and obvious bias was observed in 1 study.Three studies had obvious biases considering whether outcome assessment was blinded,outcome data was incomplete and outcome report was selective.No other apparent bias was found.Statistical analysis showed that compared with control group,intravenous antioxidants administration did not significantly reduce mortality (12.1 vs 9.7,RD=-0.02,95％ CI-0.08～-0.03,P=0.44;RR=0.83.95％ CI0.51～ 1.34,P=0.44),but could shorten LOS (MD=-2.02;95％ CI-4.00～-0.05;P=0.04).Conclusions Intravenous antioxidants could greatly shorten LOS of patients with MSAP and SAP.
