Factors associated with the relapse of propranolol-treated infantile hemangioma
10.3760/cma.j.issn.0412-4030.2017.02.001
- VernacularTitle:普萘洛尔治疗婴儿血管瘤复发因素分析
- Author:
Li LI
;
Zigang XU
;
Yujuan SUN
;
Li YAN
;
Xiaoyu LIU
;
Lin MA
- Keywords:
Hemangioma;
Infant;
Propranolol;
Recurrence;
Age factors;
Factor analysis,statistical
- From:
Chinese Journal of Dermatology
2017;50(2):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze factors associated with the relapse of propranolol-treated infantile hemangioma.Methods The clinical data were collected from 235 children with infantile hemangioma who had discontinued propranolol for 6 months,and retrospectively analyzed.Factors for the relapse of propranolol-treated infantile hemangioma were analyzed by univariate and multivariate unconditional logistic regression analyses.Results Of 235 patients followed for 6 months after drug withdrawal,66 (28.1％) were identified to have recurrence of infantile hemangioma,of whom,15 (22.7％) had severe recurrence.The risk of recurrence was significantly increased in patients taking propranolol at a daily dosage of 1.5 mg/kg compared with those taking propranolol at a daily dosage of 2 mg/kg (OR =3.566,95％ CI:1.306-9.739),in patients aged ＞ 8 weeks at the initial drug treatment compared with those aged ≤ 8 weeks at the initial drug treatment (OR =5.043,95％ CI:1.248-20.376),in patients with the course of medication ≤ 6 months compared with those with the course of medication ＞ 6 months (OR =17.661,95％ CI:4.899-63.665),as well as in patients aged ＜ 1 year at drug withdrawal compared with those aged ≥ 1 year at drug withdrawal (OR =6.089,95％ CI:1.835-20.204).Conclusion There are many risk factors associated with the relapse of propranolol-treated infantile hemangioma,so some measures aimed at these risk factors should be taken to reduce the recurrence rate.
