The relationship between vascular dementia and high-sensitivity C-reactive protein

VernacularTitle:血管性痴呆与超敏C反应蛋白相关性研究
Author: Guoyong HOU
Keywords: Vascular dementia; High-sensitivityC-reactive protein; Correlation study
From: Chinese Journal of Geriatrics 2016;35(12):1276-1278
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation of high-sensitivity C-reactive protein(hs-CRP) with the severity of vascular dementia(VaD) patients Methods All participants underwent MMSE and ADAS-cog and had their blood samples taken for hs-CRP measurement before the initiation of treatment.Patients in the Alzheimer's disease (AD)group and the VaD group received treatments according to the recommended guidelines for dementia.Patients were monitored for six months,during which each course of treatment lasted one month.Participants received assessment on the severity of dementia and underwent blood tests for hs-CRP at the conclusion of each course of treatment.Results Patients with VaD had higher hs-CRP levels than those in the control group.As the severity of dementia improved,hs-CRP levels declined accordingly.There was a statistically significant difference in hs-CRP levels between patients with moderate to severe VaD and patients with mild VaD(P＜ 0.05).Conclusions The ha-CRP level shows a higher correlation with VaD than with AD.Adjustment of treatment plans may be based on blood hs-CRP levels measured at the end of each course of treatment.