Prognosis of Asian patients with hepatocellular carcinoma with bile duct tumor thrombus after hepatic resection or liver transplantation: a Meta-analysis

VernacularTitle:肝癌合并胆管癌栓亚洲患者肝切除或肝移植手术预后分析
Author: Chenglin WANG ; Zhen CHEN ; Chiwen LIU ; Donglin SUN ; Yong JIANG
Keywords: Hepatocellular carcinoma; Bile duct tumor thrombus; Prognosis; Hepatectomy; Liver transplantation; Asian
From: Chinese Journal of Hepatobiliary Surgery 2017;23(1):20-23
CountryChina
Language:Chinese
Abstract: Objective Hepatocellular carcinoma with bile duct tumor thrombus (BDTT) is rare,and surgical treatment is currently considered as the most effective treatment.Whether resectional surgery should be carried out on these patients remains controversial.Therefore,this Meta-analysis aimed to find out the long-term survival after resectional surgical treatment.Methods We conducted a literature search on PubMed,Embase and Web of Science from inception to September 2016.11 studies were included which involved 5295 patients.Each study was evaluated using the Newcastle-Ottawa Scale.The pooled effect was calculated and the associations between BDTT and overall survival (OS) or disease-free survival (DFS)were reevaluated using Meta-analysis with hazard ratio (HR) and 95％ confidence interval (CI).Results The HR for OS and DFS was 2.34 and 1.81,the 95％ CI were 1.26 ～ 4.36 and 1.17 ～ 2.78,respectively.Conclusion HCC patients with BDTT had a bad prognosis after hepatic resection or liver transplantation.