Markers for acute rejection and immune tolerance after liver transplantation
10.3760/cma.j.issn.1007-8118.2017.02.018
- VernacularTitle:肝移植术后急性排斥反应及免疫耐受的标志物
- Author:
Ning LI
;
Wenzhe KANG
;
Rui LUO
;
Xin ZHOU
;
Zhengbin HU
;
Yanfeng WANG
;
Qifa YE
- Keywords:
Markers;
Acute rejection;
Immune tolerance;
Liver transplantation
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(2):138-141
- CountryChina
- Language:Chinese
-
Abstract:
The evaluation of the immunosuppression state in liver transplanted recipients is vital for a correct posttransplantation management and a major step towards the personalized treatment of the immunosuppression.To date,immunological monitoring after liver transplantation relies mainly on clinical judgment and pathological examination of the graft,without a proper assessment of the actual state.Previous studies have ever identified many markers for acute rejection(AR) and immune tolerance after liver transplantation.Many markers for AR are pro-inflammatory or immunoregulatory cytokines and other proteins related to inflammation.However,many markers have been proved to be also able to predict other diseases and only a few of the markers for AR have been validated.Standard liver tests cannot be used as markers for graft rejection due to the low sensitivity and specificity.This review summarized the potential markers for AR and immune tolerance after liver transplantation based on published literatures in recent years and to provide evidence for clinical application.
