Evaluation of markers and perfusion parameters in donated liver quality during machine perfusion
10.3760/cma.j.issn.1007-8118.2017.01.019
- VernacularTitle:机械灌注期间供肝质量的标志物和灌流参数评估
- Author:
Zehong FANG
;
Xiaoyan HU
;
Yanfeng WANG
;
Qifa YE
- Keywords:
Machine perfusion;
Markers;
Parameters;
Donated liver quality;
Liver transplantation
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(1):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation has become the most effective treatment option for end-stage liver diseases.The liver donation after cardiac death (DCD) had been increasingly used in clinical practice.Nevertheless,the DCD donated livers inevitably exposed to long-term ischemia and hypoxia makes the implanted organs with decreased function and more postoperative complications.Different from the conventional static cold storage,machine perfusion (MP) can be continuously used in vitro liver perfusion,which could simulate the in vivo liver status.Through the observation of ischemia injury status,we could evaluate the quality of donated liver,and thus reduce ischemia related complications.This review provides an overview and evaluation on the markers that have been investigated for the assessment of graft quality and viability testing during different types of MP.
