CXCL5/CXCR2 biological axis in pancreatic cancer
10.3760/cma.j.issn.1673-422X.2017.02.019
- VernacularTitle:CXCL5/CXCR2生物轴在胰腺癌中的研究进展
- Author:
Fan HUANG
;
Hongen JING
- Keywords:
Pancreatic neoplasms;
Chemokine CXCL5;
Receptor,interleukin-8B
- From:
Journal of International Oncology
2017;44(2):148-150
- CountryChina
- Language:Chinese
-
Abstract:
The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.
