Competing endogenous RNA and tumor pathological mechanism
10.3760/cma.j.issn.1673-422X.2017.02.009
- VernacularTitle:竞争性内源RNA与肿瘤病理机制
- Author:
Shu ZHOU
;
Na SHEN
;
Fanjun CHENG
- Keywords:
MicroRNAs;
Neoplasms;
Gene expression;
Competing endogenous RNA
- From:
Journal of International Oncology
2017;44(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
Competing endogenous RNA (ceRNA) is a class of RNA which includes mRNA,pseudogenes,long non-coding RNA (lncRNA),circular RNA (circRNA).ceRNA weakens its inhibitory effect on mRNA translation through competitive binding with shared microRNA (miRNA).Many studies have confirmed that the disorder of ceRNA is closely related to the occur-ence of breast cancer,gastric cancer,lymphoma and other tumors.With the improvement of researches,ceRNA may be used as a tumor marker of clinical diagnosis and therapeutic target.
