Observation of the effect of ganglion glycosides in the treatment of acute cerebral infarction with cognitive impairment
10.3760/cma.j.issn.1008-6706.2017.07.002
- VernacularTitle:神经节苷脂治疗急性脑梗死认知功能障碍的疗效观察
- Author:
Laichao YAN
;
Li ZHANG
;
Guobin XU
;
Jinqiang ZHU
;
Liexiang CAO
;
Meiping DONG
;
Jinbo ZHANG
;
Xiandan WU
- Keywords:
Brain infarction;
Cognition disorders;
Gangliosides
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(7):965-968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of the treatment of cognitive dysfunction of acute cerebral infarction with ganglion glycosides.Methods 83 acute cerebral infarction patients with cognitive dysfunction were selected.83 patients were randomly divided into two groups:the conventional group (41 cases) and the intervention group (42 cases).The conventional group was given conventional control infection,anti platelet aggregation and control hemorrhage of digestive tract and routine rehabilitation training for the main therapy.The intervention group was given conventional treatment plus ganglioside 100mg + 0.9％ sodium chloride 250mL,1 time a day,treatment for 21 days.Observation index:(1) total effective rate;before and after treatment,the difference of MMSE score and Barthel index.Results The total effective rate of the intervention group was higher than that of the conventional group,there was statistically significant difference (95.24％ vs.75.61％,x2 =8.245,P ＜ 0.01);Before treatment,the MMSE score,Barthel index in the two groups had no significant differences (t =0.372,0.313;P =0.711,0.756).After treatment,the MMSE score,Barthel index of the intervention group improved more significantly compared with the conventional group,the differences were statistically significant(t =7.997,25.530,all P ＜ 0.01).Conclusion The clinical effect of ganglion glycosides in the treatment of acute cerebral infarction with cognitive impairment is accurate,it can effectively reduce the patients'cognitive dysfunction,improve the ability of daily life,it is worthy of promoting.
