Role of ATP-binding Cassette Transporter G1 in Atherosclerosis
10.12007/j.issn.0258-4646.2017.04.001
- VernacularTitle:ATP结合盒转运体G1与动脉粥样硬化的研究进展
- Author:
Qu LI
;
Xiaoqian ZHANG
;
Xu LIU
;
Huiyuan ZHANG
;
Zhiyi HE
- Keywords:
ATP-binding cassette transporter G1;
atherosclerosis;
single nucleotide polymorphism
- From:
Journal of China Medical University
2017;46(4):289-293
- CountryChina
- Language:Chinese
-
Abstract:
The adenosine triphosphate (ATP)-binding cassette transporter G1 (ABCG1),a member of the superfamily of ATP-binding cassette transporters,is involved in the efflux of cholesterol and phospholipids from cells,and it maintains the intracellular hpid homeostasis.ABCG1 deficiency results in foam cell formation,endothelial dysfunction,and inflammatory reaction,and it further leads to the development and progression of atherosclerosis.However,the role of ABCG1 in atherosclerosis in animal experiments and human studies is still a debatable matter.In this paper,the recent findings on the role of ABCG1 in atherosclerotic disease are reviewed.
