Research progress of the competing endogenous RNA in primary hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2017.03.019
- VernacularTitle:竞争性内源RNA在原发性肝癌中的研究进展
- Author:
Xiaoqin HE
;
Ximing XU
- Keywords:
Liver neoplasms;
MicroRNAs;
Long non-coding RNA
- From:
Journal of International Oncology
2017;44(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Competing endogenous RNAs (ceRNAs) transcripts can communicate with microRNAs (miRNAs) through competitively binding the common miRNA response elements (MREs),which remove or decrease the repression of target genes of miRNAs.The present studies indicate that a large amount of genes,serving as ceRNAs,can promote or inhibit the occurrence of liver cancer by competing the binding site of same genes that can promote or suppress tumorigenesis.
