Pathogenesis and new therapeutic targets of liver fibrosis
10.3969/j.issn.1001-5256.2017.03.001
- VernacularTitle:肝纤维化的发病机制及治疗新靶点
- Author:
Wei ZHANG
;
Jidong JIA
- Keywords:
liver cirrhosis;
therapy;
editorial
- From:
Journal of Clinical Hepatology
2017;33(3):409-412
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the basic research on liver fibrosis has been progressed rapidly.This article briefly reviews the cellular and molecular mechanisms of liver fibrosis,including the origin of myofibroblasts,immune regulation,autophagy,and epigenetic regulation,and introduces several new therapeutic targets.More and more evidences show that successful removal of causes is the most important antifibrotic therapy.At present,although the antifibrotic drugs acting on different targets have been emerging,most of them are still in the early stage of research and development,and well-designed clinical trials are needed to confirm their clinical efficacy.
