Clinical effect of self made Jianpi Yiqi Xiaoyu decoction combined with FMC chemotherapy for treatment of elderly patients with moderate to advanced gastric cancer: results of a randomized controlled study
10.3969/j.issn.1008-9691.2017.02.016
- VernacularTitle:自拟健脾益气消瘀方联合FMC化疗方案治疗老年中晚期胃癌的临床疗效:一项随机对照研究结果
- Author:
Min DU
;
Baozhu ZENG
;
Yanyan QU
- Keywords:
Jianpi Yiqi Xiaoyu decoction;
FMC chemotherapy;
Elderly person;
Moderate to advanced gastric cancer;
Quality of life
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2017;24(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical effect of self made Jianpi Yiqi Xiaoyu decoction combined with FMC chemotherapy for treatment of elderly patients with moderate to advanced gastric cancer and its impact on their quality of life.Methods One hundred and two elderly patients with moderate to advanced gastric cancer accompanied by the Chinese medicine dialectical syndrome belonging to deficiency of spleen and stomach qi and blood stasis admitted to Zhengzhou Traditional Chinese Medicine Hospital from January 2013 to January 2016 were enrolled,they were divided into observation group and control group according to random number table method and 2 patients who missed the follow-up in each group were excluded,resulting in 49 patients in each group;the patients in the control group were treated with FMC chemotherapy [including mitomycin 15 mg/m2,cisplatin 60 mg/m2 and fluorouracil 1000 mg/m2,slow intravenous drip (drop) after dilution with 60 mL 0.9％ sodium chloride injection];the patients in observation group were treated with FMC chemotherapy combined with Jianpi Yiqi Xiaoyu decoction (consisting of astragali 30 g,codonopsis pilosula 20 g,atractylodes macrocephala 15 g,Chinese yam 15 g,hoelen 15 g,ligustici 10 g,moutan cortex 10 g,aurantii 10 g,rehmannia dride rhizome 10 g,caulis dendrobii 10 g,500 mL water was added to make a decoction,boiled and concentrated to 200 mL decoction,100 mL taken in the morning and another 100 mL in the evening orally in one day).The clinical efficacy,the change of quality of life and incidence of adverse reactions were compared between the two groups.Results The proportion of patients whose quality of life improved in the observation group was significantly higher than that in the control group [55.10％ (27/49) vs.16.33％ (8/49),P ＜ 0.05].The total effective rate was obviously higher in the observation group than that in the control group [51.02％ (25/49) vs.22.45％ (11/49),P ＜ 0.05];the incidence of reduction of hemoglobin [30.61％ (15/49) vs.63.27％ (31/49)],aleucocytosis [28.57％ (14/49) vs.67.35％ (33/49)],thrombocytopenia [28.57％ (14/49) vs.69.39％ (34/49)],nausea and vomiting [44.90％ (22/49) vs.71.43％ (35/49)],diarrhea [32.65％ (16/49) vs.63.27％ (31/49)] and neurotoxicity [34.69％ (17/49) vs.55.10％ (27/49)] were significantly lower in observation group than those in the control group (all P ＜ 0.05).Conclusions Self made Jianpi Yiqi Xiaoyu decoction combined with FMC chemotherapy can significantly improve the clinical efficacy of theelderly patients with moderate to advanced gastric cancer.It can improve the patients' quality of life and reduce the incidence of adverse reaction of chemotherapy.
