The change of serum D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease and its significance
10.3760/cma.j.issn.1008-6706.2017.07.033
- VernacularTitle:血清D-二聚体在慢性阻塞性肺疾病急性加重期中的变化及意义
- Author:
Feng YANG
- Keywords:
Pulmonary disease,chronic obstructive;
D-dimer;
Arterial blood gas;
Pulmonary function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(7):1090-1093
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of serum D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods 98 patients with COPD were selected as the research objects,including 38 patients with stable COPD and 60 patients with AECOPD.At the same time,fifty healthy subjects were enrolled in this study as healthy control group.The arterial blood gas(pH,PaCO2,PaO2,PaO2/FiO2),pulmonary function(FVC％,FEV1％,FEV1/FVC) were detected,plasma D-D were measured by immunoturbidimetry with fully automated biochemical analyzer.Results The PaCO2 of the stable COPD group and the AECOPD group were (45.30 ± 3.18) mmHg and (51.44 ± 5.12) mmHg,which were significantly higher than that of the healthy control group[(39.45 ± 4.05) mmHg] (t =4.414,7.556,all P ＜ 0.01).Tthe PaO2,PaO2/FiO2,FVC％ and FEV1/FVC were significantly lower than those of the healthy control group (t =3.618,7.702,21.433,26.316,4.323,8.302,5.112,10.384,4.191,9.511,all P ＜ 0.01).The PaCO2 of AECOPD group was significantly higher than that of the stable COPD group(t =4.331,P ＜ 0.05),while the PaO2,PaO2/FiO2,FVC％,FEV1 ％ and FEV1/FVC were significantl) lower than those of the stable COPD group(t =5.702,4.652,3.773,6.241,5.806,all P ＜ 0.05).The serum DD of the healthy control group was (0.33 ± 0.05) mg/L,which of the stable COPD group was (0.77 ± 0.08) mg/L,which of the AECOPD group was (1.58 ±0.10)mg/L,and the difference of the these groups was statistically significant(F =14.667,P ＜ 0.01).The plasma D-D of the stable COPD group and the AECOPD group were significantly higher than that of the healthy control group (t =4.667,13.224,all P ＜ 0.05).The plasma DD of the AECOPD group was significantly higher than that of the stable COPD group (t =9.471,P ＜ 0.05).There were positively correlation betweem D-D and PaCO2 (r =0.661,P ＜ 0.05),and there were negatively correlation betweem D-D and PaO2/FiO2 and FEV1/FVC(r =-0.964,-0.589,all P＜0.05).Conclusion D-dimer is correlated with arterial blood gas and lung function.D-dimer test can help to evaluate the stage and severity of COPD accurately,which is helpful for effective treatment.
