Association between γ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B
10.3969/j.issn.1001-5256.2017.03.034
- VernacularTitle:GGT与PLT比值指数对慢性乙型肝炎肝纤维化的诊断价值
- Author:
Jingjing DONG
;
Honghua GUO
- Keywords:
hepatitis B,chronic;
liver cirrhosis;
gamma-glutamyltransferase;
blood platelets;
review
- From:
Journal of Clinical Hepatology
2017;33(3):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Early and accurate diagnosis of hepatic fibrosis and application of antiviral therapy are the key to improving the prognosis of patients with chronic hepatitis B (CHB).Liver biopsy and transient elastography cannot be widely used for the diagnosis of hepatic fibrosis in clinical practice,and therefore,the serological diagnostic model has become a hot research topic in recent years.This article introduces a new serological diagnostic model,γ-glutamyl transpeptidase-to-platelet ratio (GPR),which has a high value in the diagnosis of hepatic fibrosis in CHB patients;however,the accuracy of GPR varies between different populations and different areas.GPR is also an excellent predictor for the prognosis of hepatitis B-associated liver cancer.It is pointed out that GPR has a promising future in the diagnosis of hepatic fibrosis in CHB patients,but due to a lack of clinical research data on GPR,further studies are needed to support its application in China.
