Association of rs3660 Single Nucleotide Polymorphisms with Non-Hodgkin's Lymphoma
10.12007/j.issn.0258-4646.2017.04.009
- VernacularTitle:rs3660单核苷酸多态性与非霍奇金淋巴瘤相关性研究
- Author:
Guimin ZHAO
;
Yuhuan GAO
;
Lihong LIU
;
Xiaolin WU
;
Zhe GAO
;
Lanping DIAO
- Keywords:
miR-SNP;
KRT81;
rs3660;
non-Hodgkin's lymphoma;
correlation
- From:
Journal of China Medical University
2017;46(4):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of single-nucleotide polymorphisms at the miRNA binding site rs3660 in the 3'-untranslated region of the KRT81 gene (miR-SNPs) on the cancer risk and clinical prognosis of non-Hodgkin's lymphomas (NHL).Methods The single-nucleo-tide polymorphisms of rs3660 was genotyped with ligation detection reaction method.The association of rs3660 with NHL survival was calculated with log-rank test using Kaplan-Meier method.Multivariate survival analysis was performed using a Cox proportional hazards model.Results The rs3660 genotype distribution difference was not statistically significant between the case and control group (P =0.50).Patients carrying the rs3660 CG/CC genotype exhibited a significantly longer survival time than patients carrying the GG genotype (P =0.012).In addition,rs3660 was associated independently with the survival of NHL patients in multivariate analysis (RR=0.589,95％ CI:0.415-0.832,P =0.004).The association of this miR-SNP with NHL survival was further confirmed in the peripheral T cell lymphoma (PTCL) subtype.Conclusion Our results indicate that KRT81 rs3660 GG type is an independent prognostic marker in NHL.
