Clinical analysis of morphine hydrochloride sustained-release tablets combined with celecoxib in the treatment of advanced lung cancer with moderate to severe cancer-induced pain
10.3760/cma.j.issn.1673-422X.2017.03.002
- VernacularTitle:盐酸吗啡缓释片联合塞来昔布治疗晚期肺癌伴中重度癌痛的临床分析
- Author:
Xueqin LI
;
Xi CHEN
;
Quan GONG
;
Wei SHI
;
Lijuan ZHANG
;
Hui DONG
;
Cunde WANG
- Keywords:
Lung neoplasms;
Quality of life;
Morphine;
Celecoxib;
Cancer pain
- From:
Journal of International Oncology
2017;44(3):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy,safety and life quality of patients of morphine hydrochloride sustained-release tablets combined with celecoxib in the treatment of advanced lung cancer with moderate to severe cancer-induced pain.Methods A total of 247 patients of advanced lung cancer with moderate to severe cancer-induced pain were randomly divided into combination therapy group (n =127) and morphine monotherapy group (n =120) using simple random sampling digital table method.The differences of dose,efficacy,adverse drug reactions and life quality between the two groups were analyzed.Results In achieving similar analgesic effect,the average maintenance dose of morphine in combination therapy group was (52.51 ±19.92)mg/d,lower than that in monotherapy group [(58.75 ±20.64)mg/d,t =-2.414,P =0.017].The incidence of constipation in combination therapy group was 34.6％,lower than that in monotherapy treatment group (47.5 ％,x2 =4.218,P =0.040).The life quality of the two groups were improved,and the life quality improvement rate in combination therapy group was 59.8％,higher than that in monotherapy treatment group (43.3％,x2 =6.736,P =0.009).Conclusion Morphine hydrochloride sustained-release tablets combined with celecoxib is effective in the treatment of moderate to severe cancer pain,which can reduce the dosage of morphine and reduce adverse reaction,so as to improve the life quality of the patients with advanced lung cancer.
