Regulation of myeloid-derived suppressor cells by prostaglandin E2 in tumor microenvironment
10.3760/cma.j.issn.1673-422X.2017.03.006
- VernacularTitle:前列腺素E2对肿瘤微环境中髓源性抑制细胞的调控作用
- Author:
Huilan XIE
;
Minhao ZHANG
;
Lianbing GU
;
Hongguang BAO
- Keywords:
Dinoprostone;
Bone marrow;
Cells;
Neoplasms
- From:
Journal of International Oncology
2017;44(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs),a heterogeneous population of immature myeloid cells,play an important role in immune tolerance and immune suppression.In recent years,more and more research results show that the prostaglandin E2 (PGE2) has an inseparable relationship with MDSCs,and PGE2 through its relevant receptors,regulating signal transducer and activator of transcription 3 (STAT3) and protein kinase A cell signaling pathways and secretion cytokines in tumor microenvironment,affects the development,differentiation and function of MDSCs.
