Effect and mechanism of Musashi2 and related signal pathways in genesis and progression of malignant tumor
10.3760/cma.j.issn.1673-422X.2017.03.008
- VernacularTitle:Musashi2及相关信号通路在恶性肿瘤发生发展中的作用及机制
- Author:
Jiarun LI
;
Qiaofeng GE
;
Geng GUO
;
Xiaogang WANG
- Keywords:
Neoplasms;
Mechanism;
Musashi2
- From:
Journal of International Oncology
2017;44(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
In mammals,there are two RNA-binding proteins,Musashi (Msi)1 and Msi2,constituting the Msi family.Msi2 is mainly distributed among neural,hematopoietic,gastrointestinal,pancreatic and epithelial stein cells.It is of great importance to maintain the balance between proliferation and differentiation of stem cells and regulate their growth and development.The changed expression of this protein will induce genesis and progression of malignant tumor through many kinds of signal pathways.Thus,Msi2 is trusted to provide a predictive mark and a therapeutic target for related tumors.
