Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment
10.3760/cma.j.issn.1673-422X.2017.03.012
- VernacularTitle:钠氢交换体1在肿瘤微环境中的作用
- Author:
Wei WANG
;
Xuejun YANG
- Keywords:
Acid-base equilibrium;
Neoplasm invasiveness;
Cell movement;
Tumor microenvironment;
Sodium hydrogen exchanger isoform 1
- From:
Journal of International Oncology
2017;44(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment.Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells,which plays a critical role in intracellular pH and cell volume homeostasis.NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion,which may be a potential new target in anti-cancer therapy.
