The Roles of CD137 Signaling in Atherosclerosis.
10.4070/kcj.2016.46.6.753
- Author:
In Hyuk JUNG
1
;
Goo Taeg OH
Author Information
1. Department of Life Sciences, Ewha Womans University, Seoul, Korea. gootaeg@ewha.ac.kr
- Publication Type:Review
- Keywords:
CD137;
Atherosclerosis;
T cell;
Plaque stability
- MeSH:
Animals;
Atherosclerosis*;
Cardiovascular Diseases;
Humans;
Mice;
Negotiating;
Plaque, Atherosclerotic;
Receptors, Tumor Necrosis Factor
- From:Korean Circulation Journal
2016;46(6):753-761
- CountryRepublic of Korea
- Language:English
-
Abstract:
The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
