High mobility group box 1 and its role in cervical cancer
10.3760/cma.j.issn.1673-422X.2017.03.020
- VernacularTitle:高迁移率族蛋白B1及其在宫颈癌中的作用
- Author:
Gang CHEN
;
Fangcheng ZHUANG
- Keywords:
HMGB1 protein;
Uterine cervical neoplasms;
Inflammation;
Antineoplastic agents
- From:
Journal of International Oncology
2017;44(3):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular high mobility group box 1 (HMGB1) can cause persistent inflammation via related receptors and signal pathways such as receptor for advanced glycation endproduct,Toll-like receptors and chemokines 12,which results in tumorigenesis.In patients with cervical cancer,the expression of HMGB1 increases with the rising of malignant gTade.HMGB1 participates in the genesis and development,invasion and metastasis of cancer through multiple processes.The expression of HMGB1 is inhibited by RNA interference,thus affects the invasion and migration of cervical cancer cell,which provides a new concept for the development of antineoplastic agents.
