Role of liver sinusoidal endothelial cells in the development and progression of liver fibrosis and related therapeutic strategy
10.3969/j.issn.1001-5256.2017.03.008
- VernacularTitle:肝窦内皮细胞在肝纤维化发生发展中的机制及相关治疗策略
- Author:
Yanqin DU
;
Jun WU
;
Dongliang YANG
- Keywords:
liver cirrhosis;
liver sinusoidal endothelial cells;
therapy
- From:
Journal of Clinical Hepatology
2017;33(3):438-444
- CountryChina
- Language:Chinese
-
Abstract:
Liver sinusoid endothelial cells are the first defense mechanism that protects the liver against various injuries,and they also play a significant role in the development of liver fibrosis and liver cirrhosis caused by chronic liver injury.They are involved in liver fibrosis by mediating liver inflammation,participating in sinusoid capillarization and revascularization,activating hepatic stellate cells,secreting many proinflammatory cytokines,participating in extracellular matrix formation,and mediating liver microcirculation disturbance.Clarification of these mechanisms helps to identify new targets and develop new regimens for the treatment of liver fibrosis.
