Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction.
10.4070/kcj.2016.46.6.768
- Author:
Ahmet Goktug ERTEM
1
;
Filiz OZCELIK
;
Haci Ahmet KASAPKARA
;
Cemal KOSEOGLU
;
Serdal BASTUG
;
Huseyin AYHAN
;
Cenk SARI
;
Nihal AKAR BAYRAM
;
Emine BILEN
;
Tahir DURMAZ
;
Telat KELES
;
Engin BOZKURT
Author Information
1. Department of Cardiology, Ataturk Training and Research Hospital, Ankara, Turkey. agertem@hotmail.com
- Publication Type:Original Article
- Keywords:
Inflammation;
Thrombus;
Myocardial infarction
- MeSH:
Atrial Fibrillation;
Diabetes Mellitus;
Echocardiography;
Heart Failure;
Humans;
Hypertension;
Inflammation;
Lymphocytes*;
Myocardial Infarction*;
Neutrophils*;
Stroke Volume;
Thrombosis*
- From:Korean Circulation Journal
2016;46(6):768-773
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: In this study, we examined the role of inflammatory parameters in an apical mural thrombus with a reduced ejection fraction due to large anterior myocardial infarction (MI). SUBJECTS AND METHODS: A total of 103 patients who had suffered from heart failure, 45 of whom had left ventricular apical thrombus (AT) after a large anterior MI, were enrolled in the study. A detailed clinical history was taken of each participant, biochemical inflammatory markers, which were obtained during admission, were analyzed and an echocardiographical and angiographical evaluation of specific parameters were performed. RESULTS: There were no statistically significant differences in terms of age, gender, and history of hypertension, diabetes mellitus, and atrial fibrillation between both groups (p>0.05). Similarly there were no statistically significant differences in terms of biochemical and echocardiographic parameters (p>0.05). However, there were significant differences in terms of neutrophil lymphocyte ratio (p=0.032). After a multivariate regression analysis, neutrophil lymphocyte ratio (NLR) was an independent predictor of thrombus formation (β: 0.296, p=0.024). The NLR >2.74 had a 78% sensivity and 61% specifity in predicting thrombus in patients with a low left ventricular ejection fraction. CONCLUSION: In this study, neutrophil lymphocyte ratios were significantly higher in patients with apical thrombus.
