Genetic polymorphism of rs9574 C/G of endothelial cell protein C receptor gene in Guangxi population
10.13315/j.cnki.cjcep.2017.03.004
- VernacularTitle:广西人群EPCR基因3'-非编码区rs9574C/G位点的多态性
- Author:
Yanbing LIANG
;
Dingwei PENG
;
Yuqing HUANG
;
Yesheng WEI
;
Weigui LUO
;
Jun LI
;
Pinhu LIAO
- Keywords:
endothelial cell protein C receptor;
polymorphism;
Guangxi
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(3):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To compare the difference of the genotype and allele of endothelial cell protein C receptor (EPCR)gene rs9574 C/G between Guangxi population and other ethnic groups.Methods The rs9574 C/G polymorphisms of EPCR in 130 cases of Guangxi population were detected by PCR and DNA sequencing.The distribution frequency of allele and genotype was compared with the other four ethnic groups (HapMap-CEU,HapMap-HCB,HapMap-JPT,HapMap-YRI),which was published by the human genome project.Results Three genotypes of CC,CT and TT were found in rs9574 C/G with the frequencies of 39.2％,46.2％,14.6％ respectively.the allele frequencies of C,T were 62.3％ and 37.7％.No significant difference was observed in the frequency of genotype and allele between male and female (P ＞ 0.05).There were significant differences in the genotype distribution among Guangxi population,HapMap-CEU and HapMap-YRI (P ＜ 0.05).Significant differences of allelic frequency were found among Guangxi population,HapMap-CEU,HapMap-JPT and HapMap-YRI.Condusion The polymorphisms of rs9574C/G in 3'-noncoding region of EPCR gene in Guangxi population were different in different regions and ethnic groups.
