Sleep architecture in drug naive patients with schizophrenia: A meta-analysis
10.3969/j.issn.1000-6729.2017.03.006
- VernacularTitle:未用药精神分裂症患者睡眠结构的meta分析
- Author:
Yun BIAN
;
Weiye LIANG
;
Weihua YUE
;
Xiaole HAN
;
Chen LIN
;
Jing ZHANG
;
Zhixiong WANG
;
Botao MA
- Keywords:
schizophrenia;
sleep architecture;
slow wave sleep;
cognitive function;
meta-analysis
- From:
Chinese Mental Health Journal
2017;31(3):208-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the characteristics change of sleep architecture in drug naive patients with schizophrenia,compared with healthy control.Methods:The key words including schizophrenia and sleep architecture (or sleep structure or sleep disturbance or polysomnogram and so on) were used to search literatures in MEDLINE,Embase,Springer,PsychINFO,google scholar,Wanfang data,published from 1980 to 2015.Fifteen studies that compared sleep architecture in drug naive patients with schizophrenia and healthy control were included.Literature quality evaluation was performed with the Newcastle-Ottawa Scale.The meta-analysis was performed by using Stata13.0 software.Results:Compared to healthy control,the total sleep time decreased (P ＜ 0.01),the sleep latency increased (P ＜ 0.01),the sleep efficiency decreased (P ＜ 0.01),and the rapid-eye-movemem (REM) sleep latency increased (P ＜ 0.01) significantly in drug naive patients with schizophrenia.The proportion of stage1 was increased,and the proportions of stage4 and slow wave sleep stage were decreased,the differences between case and control were statistically significant.Conclusion:In the control of drug effects,patients with schizophrenia may have poorer sleep quality of be poorer than healthy controls,such as the decreased total sleep time,specifically slow wave sleep,prolonged sleep latency and decreased sleep efficiency.
