Effects of curcumin on pulmonary functions and the expression of TGF-β1 and NF-κB of paraquat-induced pulmonary fibrosis of rats
10.3760/cma.j.issn.1671-0282.2017.04.007
- VernacularTitle:姜黄素对百草枯中毒致肺纤维化大鼠肺功能及TGF-β1、NF-κB表达的影响
- Author:
Yan TANG
;
Rongjia YANG
;
Honggang CHEN
;
Xiaoyan FU
;
Jun XU
;
Youfan FENG
;
Shijie LIU
;
Shikui ZHANG
;
Lijun HOU
- Keywords:
Paraquat;
Pulmonary fibrosis;
Curcumin;
Pulmonary functions;
TGF-β1;
NF-κB懂
- From:
Chinese Journal of Emergency Medicine
2017;26(4):392-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effects and the possible mechanismof curcumin on pulmonary functions and expression of TGF-β1 and NF-κB in paraquat-induced pulmonary fibrosis of rats.Methods SPF Wistar rats were randomly (random number) divided into three groups:paraquat-poisoned group (PQ group,with PQ 50 mg/kg by gavage),Curcumin-treatment group (PC group after 30,with curcumin (200 mg/kg) by intraperitoneal injection),and Blank group (B group,with same volume of sterile saline at the same time).After 14 d,the lung function of rats was observed,and the expression of TGF-β1 and NF-κB protein were detected by immunohistochemistry.Results The survival rates of mice significant difference in the PC and PQ groups with (70.83％ vs.41.67％,P ＜0.05).Compared with the B group,lung function index (Te,PIF,PEF,EF50,TV,F) of PQ group significantly decreased (P ＜ 0.05,P ＜ 0.01).Compared with the PQ group,lung function index (Te,PEF,TV,F) of PC group significantly increased (P ＜ 0.05 or P ＜ 0.01).There are some expression of lung tissues of rats with TGF-β1,NF-κB in B group.Compared with B group,PQ group significantly enhanced (P ＜0.01or P ＜0.05).Compared with the PQ,PC group significantly decreased (P ＜ 0.01 or P ＜ 0.05).Conclusions Curcumin can relieve paraquat-induced pulmonary fibrosis by inhibiting the over expression of TGF-β1,NF-κB in lung tissue of rats.
