Meta-analysis of split-dose and single-dose of polyethylene glycols for morning colonoscopy

VernacularTitle:复方聚乙二醇分次与单次给药用于早晨结肠镜肠道准备效果的荟萃分析
Author: Dong WU ; Wei HAN ; Yunlu FENG ; Jingnan LI ; Aiming YANG ; Jiaming QIAN
Keywords: Adenoma; Colonoscopy; Adenoma detection rate; Bowel preparation; Polyethylene glycols
From: Chinese Journal of Digestive Endoscopy 2016;33(12):842-846
CountryChina
Language:Chinese
Abstract: Objective To evaluate the performance of split-dosed polyethylene(PEG) for colonoscopy preparation.Methods Split-dose means that 1-3 L of PEG is taken in the afternoon or evening before examination and the remains in the next morning.And single-dose refers to all PEG is taken in the evening before ex-amination.A meta-analysis was conducted to compare bowel preparation quality,adenoma detection rate and patients' acceptance between groups.Results Ten randomized controlled trials were included into this study with 3 222 participants(1 481 in split-dose group and 1 741 in single-dose group).Split-dose group had higher rate of satisfactory bowel preparation(OR=3.37,95％CI:2.37-4.79),and so did the subgroup of 2～ 3 L PEG (OR =3.88,95％ CI:2.39-6.29).Split-dose group did not improve adenoma detection rate significantly (OR =0.94,95％ CI:0.71-1.24),but reported less adverse events such as nausea (OR =0.56,95％ CI:0.42-0.74)and vomiting(OR=0.51,95％CI:0.30-0.88).Conclusion Split-dosed PEG provides better colon cleansing with higher patient compliance,but does not improve detection rate of adenoma.