Diagnostic value of endoscopic submucosal dissection for gastric intraepithelial neoplasia
10.3760/cma.j.issn.1007-5232.2016.12.002
- VernacularTitle:诊断性内镜黏膜下剥离术在胃上皮内瘤变性质诊断中的应用价值
- Author:
Huanhuan SUN
;
Wei GONG
;
Silin HUANG
;
Yali ZHANG
;
Fachao ZHI
;
Side LIU
;
Yang BAI
- Keywords:
Stomach;
Intraepithelial neoplasia;
Diagnostic endoscopic submucosal dissection;
Magnifying endoscopy combined with digitalchromoendoscopy
- From:
Chinese Journal of Digestive Endoscopy
2016;33(12):820-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate diagnostic endoscopic submucosal dissection(D-ESD) for gastric intraepithelial neoplasia(GIN).Methods From January 2012 to May 2016,64 patients with biopsy-proven LGIN who accepted magnifying endoscopy combined with digitalchromoendoscopy(ME-DCE) and D-ESD in Gastrointestinal Endoscopy Center of Nanfang Hospital affiliated to Southern Medical University were retrospectively analyzed in this study.The consistency of ME-DCE prediction with D-ESD pathologic outcome was analyzed by using Kappa test.According to D-ESD pathologic outcome,the two groups were analyzed with independent t-test,chi-square test,or Fisher's exact probability test.Results Sixty-four patients with biopsyproven LGIN were enrolled;25 and 39 patients were predicted by ME-DCE as LGIN and HGIN/differentiated adenocarcinoma respectively;27 and 37 patients were diagnosed as LGIN and HGIN/differentiated adenocarcinoma by D-ESD respectively.ME-DCE prediction was well consistent with D-ESD pathologic outcome(k =0.676).According to pathologic outcome of D-ESD,no significant difference was observed in lesion size,biopsy amount,D-ESD sample size,complete resection rate,operation time period,complications,length of hospital stay,or in-hospital cost(P＞0.05).Conclusion ME-DCE can be proposed when the endoscopic biopsy indicates LGIN.And D-ESD should be performed for definitive diagnosis when the MEDCE indicates HGIN/differentiated adenocarcinoma.
