Effect of hyperlipidemia on pulmonary uptake in patients inhaling sevoflurane for anesthesia
10.3760/cma.j.issn.0254-1416.2017.01.017
- VernacularTitle:高脂血症因素对患者吸入七氟醚麻醉时肺摄取的影响
- Author:
Yanqiu LIU
;
Yimin REN
;
Hong GAO
;
Ke JIANG
;
Li ZENG
;
Xingwei ZHANG
- Keywords:
Hyperlipemia;
Anesthetic,inhalation;
Pulmonary uptake;
Pharmacokinetics
- From:
Chinese Journal of Anesthesiology
2017;37(1):74-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of hyperlipidemia on pulmonary uptake in the patients inhaling sevoflurane for anesthesia.Methods A total of 103 patients of both sexes,aged 20-50 yr,with body mass index of 18-25 kg/m2,of American.Society of Anesthesiologists physical status Ⅰ or Ⅱ,undergoing elective operation under general anesthesia,were enrolled in the study.Anesthesia was induced with iv midazolam 0.1 mg/kg,vecuronium 0.1 mg/kg,fentanyl 0.l mg/kg and etomidate 0.3 mg/kg.Patients were mechanically ventilated after endotracheal intubation.Patients inhaled 2％ sevoflurane for 30 min at an oxygen flow rate of 2 L/min.The inspired concentrations (Fi) and expired concentrations (Fe,Fe≈alveolar concentration [Fa]) of sevoflurane were recorded at 1,3,5,7,10,15,20 and 30 min of inhalation (T0-7).Patients were divided into either control group group C) or hyperlipidemia group (group H) according to the results of blood lipid levels after the end of observation.The ratio of Fa/Fi and time spent in reaching the titration value (Fa/Fi =0.8) were calculated in each group.Results There were 67 cases in group C and 36 cases in group H.Compared with group C,the Fa/Fi ratio was significantly decreased at 5,7 and 10 min of inhalation,and the time spent in reaching the titration value was prolonged in group H (P ＜ 0.05).Conclusion The pulmonary uptake of sevoflurane is increased,which may be associated with increased blood/gas partition coefficient.
