- Author:
Eun Ju CHUNG
1
;
Ji Young LEE
;
Jaewon CHOE
;
Hye Sook CHANG
;
Jongcheol KIM
;
Dong Hoon YANG
;
Byong Duk YE
;
Jeong Sik BYEON
;
Kyung Jo KIM
;
Suk Kyun YANG
;
Jin Ho KIM
;
Seung Jae MYUNG
Author Information
- Publication Type:Original Article
- Keywords: Chicken skin mucosa; Colorectal adenoma; Carcinogenesis; Colonoscopy
- MeSH: Adenoma*; Adenoma, Villous; Carcinogenesis; Chickens*; Chungcheongnam-do; Colon*; Colonoscopy; Cross-Sectional Studies; Health Promotion; Humans; Macrophages; Mass Screening; Mucous Membrane*; Multivariate Analysis; Pathology; Polyps; Prevalence; Skin*
- From:Intestinal Research 2015;13(4):318-325
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Chicken skin mucosa (CSM), surrounding colorectal adenoma, is an endoscopic finding with pale yellow-speckled mucosa; however, its clinical significance is unknown. This study aimed to evaluate the prevalence and clinical characteristics of CSM, and the association between colorectal carcinogenesis and CSM. METHODS: This cross-sectional study was performed in 733 consecutive patients who underwent endoscopic polypectomy for colorectal adenoma after the screening of colonoscopy at the Asan Health Promotion Center between June 2009 and December 2011. The colonoscopic and pathological findings of colorectal adenoma including number, size, location, dysplasia, morphology, and clinical parameters were reviewed. RESULTS: The prevalence of CSM was 30.7% (225 of 733 patients), and most CSM-related adenomas were located in the distal colon (93.3%). Histological analysis revealed lipid-laden macrophages in the lamina propria of the mucosa. Multivariate analyses showed that CSM was significantly associated with advanced pathology, including villous adenoma and high-grade dysplasia (odds ratio [OR], 2.078; 95% confidence interval [CI], 1.191-3.627; P=0.010), multiple adenomas (i.e., > or =2 adenomas; OR, 1.692; 95% CI, 1.143-2.507; P=0.009), and a protruding morphology (OR, 1.493; 95% CI, 1.027-2.170; P=0.036). There were no significant differences in polyp size or clinical parameters between patients with and without CSM. CONCLUSIONS: CSM-related adenoma was mainly found in the distal colon, and was associated with advanced pathology and multiple adenomas. CSM could be a potential predictive marker of the carcinogenetic progression of distally located colorectal adenomas.