The clinical application value of serum hs-CRP, IL-1β and Lp-PLA2 in ACS
10.3760/cma.j.issn.1008-1372.2017.01.018
- VernacularTitle:急性冠脉综合征患者血清hs-CRP、IL-1β和Lp-PLA2检测的临床意义
- Author:
Manlin XIANG
;
Yunlai LIANG
;
Xulin XIE
;
Shiyang QIU
;
Bin YI
- Keywords:
Coronary artery disease/ME/DI;
C-reactive protein/ME;
Interleukin-1 beta/;
Phospholipases A2/ME;
Lipoproteins/ME
- From:
Journal of Chinese Physician
2017;19(1):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of high sensitivity C-reactive protein (hsCRP),interleukin-1β (IL-1β) and lipoprotein-associated phospholipase A2 (Lp-PLA2),and investigate their clinical diagnostic value in acute coronary syndrome (ACS) patients.Methods Fifty three clinical serum samples of patients specifically diagnosed with acute coronary syndrome were collected.A total of 21 healthy subjects were enrolled as healthy controls.Serum IL-1β and Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay.The concentration of hs-CRP was tested by immunoturbidimetry method.Results Compared to the healthy controls,the levels of serum hs-CRP,IL-1βand Lp-PLA2 were significantly higher in ACS and ACS subgroups (P ＜ 0.05),respectively.The level of Lp-PLA2 was gradually increased among healthy controls,angina pectoris (AP),ST-segment elevation myocardial infarction (STE-MI),non-ST-segment elevation myocardial infarction (NSTEMI) groups.The best cut-off value of hs-CRP,IL-1β and Lp-PLA2 was 7.44 mg/L,90.88 ng/L and 219.92 μg/L,respectively.The parallel test had better sensitivity (94.3％) and specificity (100％).Conclusions Serum hs-CRP,IL-1β and Lp-PLA2 play an important role in classifying the clinical types and monitoring the conditions of patients with ACS.Combination of hs-CRP,IL-1β and Lp-PLA2 is expected to be a new biomarker for ACS.
