Research progress in liver regeneration of cirrhosis
10.3760/cma.j.issn.1673-9752.2017.02.019
- VernacularTitle:肝硬化肝再生的研究进展
- Author:
Xinqiang WU
;
Yajin CHEN
- Keywords:
Liver neoplasms;
Liver cirrhosis;
Liver regeneration;
Hepatectomy
- From:
Chinese Journal of Digestive Surgery
2017;16(2):210-214
- CountryChina
- Language:Chinese
-
Abstract:
Compared with the regeneration ability of normal liver,that of liver with cirrhosis is so weak that its reserve function is insufficient,resulting in a great increase of chance of liver failure after partial hepatectomy,and limiting the development of major hepatectomy.It has been demonstrated that the hepatocytes of cirrhosis still possess the suppressed ability of regeneration.The morphological structures as well as physiological functions of regenerated hepatocytes are not complete.The important mechanisms leading to the impairment of regeneration ability include pathophysiologic changes such as excessive deposition of extracellular matrix and the capillarization,the imbalance of energy metabolism of hepatocytes and disruptive secretion of sinus endothelial cells and so on.The clinical observation is that many factors can stimulate the regeneration of liver with cirrhosis,including radiofrequency ablation,partial hepatectomy,associated liver partition and portal vein ligation for staged hepatectomy,splenectomy,drugs,cell transplantation,tokines et al.It is of great significance to promote the regeneration ability of liver with cirrhosis associated with various approaches reasonably for enhancing the security of partial hepatectomy and treatment of end-stage liver diseases.
