Research progress on extraintestinal cutaneous manifestation of Crohn's disease

VernacularTitle:克罗恩病肠外皮肤表现的研究进展
Author: Jiwen ZHOU ; Zhizhong XU ; Guidong SUN ; Hongjin CHEN ; Bolin YANG
Keywords: Crohn's disease; Extraintestinal manifestations; Cutaneous manifestations
From: Chinese Journal of Digestive Surgery 2016;15(12):1220-1225
CountryChina
Language:Chinese
Abstract: Crohn's disease (CD) is a chronic nonspecific inflammatory disease.CD can affect any location in the digestive tract,and it also affect other organs,including the eyes,skin,liver and joints,which are termed extraintestinal manifestations (EIMs).The cutaneous manifestations of CD are common and occur in about one-third of patients.EIMs of CD have been divided into 3 categories.(1) Specific lesion,cutaneous manifestations of CD were the same as histopathologic findings of underlying gastrointestinal lesion.(2) Reactive lesion,it was also inflammatory lesion which was usually accompanied by underlying gastrointestinal disease while inflammatory injury was different from histopathologic findings of gastrointestinal lesion.(3) Associated lesion,it was caused by sequelae of human leucocyte antigen and chronic inflammation.In the current era of ever-expanding therapeutic options for CD,some investigators have proposed a fourth category of EIMs,namely those that are therapy-related lesion.The therapy-related lesion is closely related to disease-associated conditions in light of certain skin findings,and there is potential overlap between them.