Platelet Additive Solutions.
- Author:
Jin Hyuk YANG
1
;
So Yong KWON
;
Juyeon LEE
;
Yong Hun JEE
;
Myunghan KIM
Author Information
1. Blood Transfusion Research Institute, Korean Red Cross, Seoul, Korea. sykwon@redcross.or.kr
- Publication Type:Review
- Keywords:
Platelet additive solution;
Plasma;
Buffy coat method
- MeSH:
Blood Platelets*;
Citric Acid;
Electrolytes;
Employment;
Glucose;
Hypersensitivity;
Korea;
Metabolism;
Plasma;
Platelet Activation;
Social Control, Formal
- From:Korean Journal of Blood Transfusion
2013;24(3):207-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Storage of platelet concentrates in platelet additive solution (PAS) with plasma removal has many advantages, including reduction of allergic reactions, contributing to the available plasma pool for fractionation or transfusion, and employment of pathogen reduction technology. In order to decrease platelet activation for improvement of in vivo viability, PAS should be designed for optimization of aerobic metabolism using compounds such as glucose, acetate, citrate, phosphate, and electrolytes. After a thorough discussion, particularly on the efficacy and regulations, use of the buffy coat method as well as application of a new generation of PAS may likely be the future direction of platelet storage in Korea.
