NK and NKT cells in acute pancreatitis

VernacularTitle:自然杀伤细胞和自然杀伤T细胞在急性胰腺炎病程中的变化
Author: Zhining LIU ; Xiaoping GENG ; Shengyun WAN ; Hui HOU ; Zongfan YU
Keywords: Pancreatitis; Immunity,cellular; Flow cytometry
From: Chinese Journal of General Surgery 2016;31(12):1031-1033
CountryChina
Language:Chinese
Abstract: Objective To investigate natural killer(NK) and NKT cells in acute pancreatitis(AP).Methods Changes of NK and NKT cells in peripheral blood of 86 AP cases were detected using muhiparameter flow cytometry.Results Compared with control group,the NKT cells decreased in AP patients (t =5.23,P =0.00),but NK cells didn't (t =-1.15,P =0.25).NKT cells in severe SAP and mnoderate MAP were lower than that in the control group (t =-3.92,P =0.00;t =4.84,P =0.00).There was no statistically significant difference of NK cells between MAP and the controls (t =-0.54,P =0.59),but NK cells in SAP group was obviously higher than that in control group (t =3.12,P =0.00).After one week treatment,NK cells significantly decreased (t =8.43,P =0.00).NKT cells were higher than control group (t =-4.44,P =0.00).Dynamic monitoring in AP patients found continuous declination in NK cells,and NKT cells experienced an increase before a falling.Conclusion Monitoring of NK and NKT cells can be used as an important index for the severity and response to treatment in acute pancreatitis.