Effect of creatine phosphate sodium on postoperative cognitive function of patients undergoing off-pump coronary artery bypass grafting
10.3760/cma.j.issn.0254-1416.2016.10.003
- VernacularTitle:磷酸肌酸钠对非体外循环冠状动脉旁路移植术患者术后认知功能的影响
- Author:
Ling ZHANG
;
Tao JIANG
;
Gao CHENG
;
Yuanhai LI
- Keywords:
Coronary artery bypass,off-pump;
Phosphocreatine;
Cognition disorders
- From:
Chinese Journal of Anesthesiology
2016;36(10):1175-1178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of creatine phosphate sodium on postoperative cognitive function of the patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods Forty patients of both sexes,aged 52-70 yr,weighing 52-84 kg,of American Society of Anesthesiologists physical status Ⅲ,scheduled for elective OPCABG,were divided into either creatine phosphate sodium group (group CPS) or control group (group C) using a randon number table,with 20 patients in each group.Total intravenous anesthesia was applied during operation to maintain bispectral index value at 40-60 and hemodynamics stable.After induction of anesthesia,creatine phosphate sodium 15 mg/kg (in 100 ml of normal saline) was infused over 30 min via the central vein in group CPS,and the equal volume of normal saline was infused over 30 min instead of creatine phosphate sodium in group C.Postoperative visual analogue scale scores were maintained ≤ 3.Before induction of anesthesia,immediately after the end of operation,and at 24 and 48 h after operation,arterial blood samples were collected for determination of serum C-reactive protein concentrations by immunoturbidimetry.The cognitive function was assessed on day 1 before operation and day 7 after operation,and the development of postoperative cognitive dysfunction was recorded.Results Compared with group C,the concentrations of serum C-reactive protein at 24 and 48 h after operation and incidence of postoperative cognitive dysfunction were significantly decreased in group CPS (P＜0.05).Conclusion Creatine phosphate sodium can improve postoperative cognitive function of the patients undergoing OPCABG.
