Protective mechanisms of hypoxia-inducible factor 1α against liver ischemia reperfusion injury
10.3760/cma.j.issn.1007-8118.2016.12.019
- VernacularTitle:缺氧诱导因子1α在肝缺血再灌注损伤中的保护作用机制
- Author:
Xingjian ZHANG
;
Xiaoli FAN
;
Yanfeng WANG
;
Qifa YE
- Keywords:
Hypoxia-inducible factor 1α;
Liver ischemia-reperfusion injury;
Liver transplantation
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(12):858-861
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factors 1α (HIF-1α) is the key cellular oxygen-sensitive transcription factors that could activate diverse pathways in regulating cellular metabolism,angiogenesis,proliferation and migration,enabling a cell to generate adaptive responses to a low oxygen or hypoxic environment.HIF-1 α has been shown to play an important role in the pathogenesis of multiple liver diseases.This review explores the impact of HIF1α on liver ischemia-reperfusion injury and liver transplantation as well as its mechanism.
