Association of serum levels of matrix metalloproteinases and their tissue inhibitors with mortality in patients with malignant middle cerebral artery infarction
10.3760/cma.j.issn.1008-1372.2016.11.019
- VernacularTitle:基质金属蛋白酶及其组织抑制剂水平与恶性大脑中动脉梗死患者死亡率的关系
- Author:
Yiwen CHEN
;
Geng LI
;
Lijun LU
- Keywords:
Matrix metalloproteinase 9/ME;
Matrix metalloproteinase 10/ME;
Tissue inhibitor of metalloproteinase-1/ME;
Infarction,middle cerebral artery/ME;
Mortality
- From:
Journal of Chinese Physician
2016;18(11):1671-1673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) and the mortality in patients with malignant middle cerebral artery infarction.Methods A total of 74 patients with malignant middle cerebral artery infarction (MMCAI) was assigned to research group,74 healthy volunteers were recruited to serve as healthy controls,and 242 patients with other cerebral infarction were recruited to serve as case controls.Quality-of-life questionnaire and clinical examination were used to collect the information of participants.Endpoint was 30-day mortality.Results The research group showed higher serum levels of MMP-9,MMP-10,and TIMP-1 relative to the case control group,and the case control group showed higher serum levels of MMP-9,MMP-10,and TIMP-1 relative to the healthy control group (P ＜ 0.05).Compared to survivor ones,non-surviving MMCAI patients showed lower Glasgow Coma Scale score (P ＜ 0.05),higher serum levels of tumor necrosis factorα (TNF-α),MMP-9,MMP-10,and TIMP-1 (P ＜ 0.05).Multiple logistic regression analysis showed that serum levels of TNF-α,MMP-9,MMP-10,and TIMP-1 were associated with 30-day mortality,and the OR were 1.09,1.18,1.13,and 1.32,respectively.Conclusions Serum levels of MMP-9,MMP-10,and TIMP-1 levels in MMCAI patients were associated with mortality,and could be used as an auxiliary index of mortality in MMCAI patients.
