Expression of D J-1 protein in endometrial carcinoma tissue and its correlation with prognosis
10.3760/cma.j.issn.1008-1372.2016.11.020
- VernacularTitle:子宫内膜癌中DJ-1表达及其与预后的关系
- Author:
Yuqi GAO
;
Jiajie WU
;
Yanhua ZHAO
;
Xinyi LIU
;
Jing WANG
;
Fang ZHU
- Keywords:
Endometrial neoplasms/ME;
Oncogene proteins/ME;
Prognosis
- From:
Journal of Chinese Physician
2016;18(11):1674-1678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of DJ-1 protein in the endometrial carcinoma and delineate its functional roles in endometrial carcinoma progression.Methods Expression of DJ-1 was examined with immunohistochemical staining of 69 paraffin-embedded endometrial carcinoma samples who underwent surgery at Hunan province Tumor Hospital.Kaplan-Meier analysis was performed to describe the survival curve.Univariate and multivariate analyses were performed with COX proportional hazard model.Results (1) The expression of DJ-1 protein in endometrial carcinoma was significantly higher than that in normal endometrial tissues (P ＜ 0.05).(2) There was positive correlation between the high expression of DJ-1 protein in endometrial carcinoma samples and the pathological grade,the International Federation of Gynecology and Obstetrics (FIGO) stage,depth of myometrial invasion,or lymph node metastasis (P ＜ 0.05).(3) Kaplan-Meier analysis indicated that the cumulative 5-year survival rate in the low-DJ-1 expression group was 80.8％,whereas it was only 51.2％ in the high-DJ-1 expression group (P ＜ O.05).COX analysis indicated that the expression of DJ-1 was not the endometrial carcinoma independent prognostic factors for overall survival time (P ＞ 0.05).Conclusions The high expression of DJ-1 protein in endometrial carcinoma samples demonstrated a significantly positive correlation with the pathological grade,FIGO stage,depth of myometrial invasion,and lymph node metastasis.However,DJ-1 is not enough to be independent prognostic factor for overall survival time.
