Concentration of serum Hcy and its relationship with other biochemical indexes in preeclampsia
- Author:
Hien Minh Nguyen
;
Ngoc Thien Pham
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Preeclampsia
- MeSH:
Homocysteine;
Preeclampsia
- From:Journal of Medical Research
2008;54(2):34-40
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, affecting 5 - 6% of all pregnancies. Recently, homocysteine (Hcy), a metabolite of amino acid methionine has been postulated producing oxidative stress, endothelial cell dysfunction, and alterations associated with preeclampsia. It is unclear whether high concentration of circulating Hcy causes preeclampsia, or whether this is a secondary phenomenon of metabolic alterations resulting from the disorder. Objectives: (1) Determining blood Hcy concentration in pregnancies in various severities of preeclampsia. (2) Discover the relationships between serum Hcy and other biological markers in preeclampsia. Subjects and method: This descriptive cross-sectional study consisted of 3 groups of pregnancies admitted to Thanh Nhan Hospital: 24 normal pregnant women, 28 pregnancies with non-serious preeclampsia, and 27 pregnancies with serious preeclampsia. Concentrations of blood Hcy of all participants were assayed by a competition fluorescence immunoassay (FPIA). Results: The mean concentration of serum Hcy during normal pregnancy was 5.2+/-1.0micromol/L compared with 7.1+/-1.8micromol/L among pregnancies with non-serious preeclampsia, and 11.7+/-2.9micromol/L among pregnancies with serious preeclampsia. Serum Hcy increased in pregnancies with renal dysfunction, elevated serum uric acid, and injuries of liver cells. Conclusion: Concentration of the serum Hcy in pregnancies with serious preeclampsia is significantly higher than that of pregnancies with non-serious preeclampsia, and the serum Hcy in pregnancies with non-serious preeclampsia is significantly higher than that of normal pregnancies. There are relationships between elevated serum Hcy in preeclampsia with level of kidney failure, injury of liver and increased levels of serum uric acid.
