Effects of Astragalus Injection Combined with Salmeterol Propionate Powder Inhalation on Pulmonary Func-tion,Cytokines and Blood Rheology Indexes of COPD Patients
10.6039/j.issn.1001-0408.2016.26.24
- VernacularTitle:黄芪注射液联合沙美特罗替卡松粉吸入剂对COPD患者肺功能、细胞因子和血液流变学指标的影响
- Author:
Cuirong XU
;
Kunlin JIA
;
Xiaoli ZHONG
;
Dan YU
;
Qing GAO
;
Hongping LI
;
Linyu LI
- Publication Type:Journal Article
- Keywords:
Astragalus injection;
Salmeterol propionate powder inhalation;
Chronic obstuctive pulmonary disease;
Therapeutic efficacy;
Pulmonary function;
Cytokine;
Blood rheology
- From:
China Pharmacy
2016;27(26):3678-3680
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Astragalus injection combined with Salmeterol propionate powder inhala-tion on pulmonary function,cytokines and blood rheology indexes of Chronic obsrnctine pulmonary disease (COPD) patients. METHODS:104 COPD patients were divided into observation group and control group according to the randorn number table meth-od,with 52 cases in each group. Control group was given routine symptomatic treatment+Salmeterol propionate powder inhalation 1 dose,bid;observation group was additionally given Astragalus injection 30 ml added into 5% Glucose injection 250 ml,ivgtt, qd,on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. Clinical efficacy,pulmonary function indexes [forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC],CRP,cytokine [IL-6,IL-8,TNF-α] levels,blood rheology indexes (whole blood high-shear viscosity,whole blood low-shear viscosity,fibrinogen,hematokrit and plasma viscosity),and the occurrence of ADR were observed in 2 groups. RESULTS:The total effective rate of observation group (94.23%)was significantly higher than that of control group(75.00%);compared with before treatment,FEV1,FVC and FEV1/FVC of 2 groups were significantly increased after treatment,and those of observation group were significantly higher than those of control group;CRP,IL-6,IL-8 and TNF-α of 2 groups were significantly decreased,and those of observation group were signifi-cantly lower than those of control group. The whole blood high-shear viscosity,whole blood low-shear viscosity,fibrinogen,hema-tocrit and plasma viscosity of observation group were decreased significantly after treatment,and the observation group was signifi-cantly lower than the control group,with statistical significance(P<0.05). No significant ADR was found in 2 groups. CONCLU-SIONS:Astragalus injection combined with Salmeterol propionate powder inhalation is significantly effective for COPD,improves pulmonary function of patients,improves micro inflammatory state and decreases blood rheology indexes with good safety.
