Effect of Rosuvastatin on Prognostic of Patients with Paroxysmal Atrial Fibrillation after Circumferential Pul-monary Vein Ablation
10.6039/j.issn.1001-0408.2016.26.34
- VernacularTitle:瑞舒伐他汀对阵发性心房颤动患者环肺静脉消融术预后的影响
- Author:
Anning ZENG
;
Jian SHI
;
Jixi YU
;
Rongxing CHEN
;
Qinyu YANG
;
Bingbing CAI
;
Degao XIONG
- Publication Type:Journal Article
- Keywords:
Paroxysmal atrial fibrillation;
Circumferential pulmonary vein ablation;
Rosuvastatin;
Atrial effective refrac-tory period;
Prognostic
- From:
China Pharmacy
2016;27(26):3705-3707
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of rosuvastatin on prognostic of patients with paroxysmal atrial fibrillation (AF) after circumferential pulmonary vein ablation. METHODS:75 patients with paroxysmal AF were divided into observa-tion group(n=39)and control group(n=36)according to the admission single. All patients underwent circumferential pulmo-nary vein ablation antiarrhythmic treatment. Control group orally received warfarin sodium,amiodarone,metoprolol,and sub-cutaneous injected low molecular weight heparin. Observation group additionally received 10 mg Rosuvastatin tablet,qd on the basic of contol group. Changes of cardiac function,inflammatory factors,lipid levels in 2 groups before and after treat-ment were observed,and follow-up results were compared. RESULTS:There was no significant difference in left atrial diame-ter and left ventricular ejection fraction in 2 groups before and after treatment (P>0.05);atrial effective refractory periods (AERP)in 2 groups significantly prolorged,and observation group prolorged more significantly than control group,the differ-ence was statistically significant(P<0.05). Serum high sensitivity C-reactive protein,interleukin-6 48 h and 1 month after op-eration in 2 groups significantly increased,and control group was significantly higher than observation group,the difference was statistically significant (P<0.05);before operation and after 3 months of operation,there was no significant difference in inflammatory cytokine levels(P>0.05). Triglyceride and low density lipoprotein cholesterol in observation group 1 month after operation significantly decreased, HDL-C significantly increased, there were significant differences (P<0.05). Fol-low-up time was (23.91 ± 5.28) months,AF recurrence was 7.8%,which was significantly lower than control group (13.9%),the difference was statistically significant (P<0.05);and there were no significant differences in ablation-related atrial tachycardia (ATa) and the incidence of adverse reactions between 2 groups (P>0.05). CONCLUSIONS:Rosuvastatin can effectively inhibit the inflammatory reaction and prolong the AERP,thereby reducing the recurrence rate of AF,with good efficacy and safety.
