Clinical Observation of Compound Sabal Berry Tablet Combined with Tamsulosin in the Treatment of Benign Prostatic Hyperplasia Complicated with Urinary Obstruction
10.6039/j.issn.1001-0408.2016.24.17
- VernacularTitle:复方蓝棕果片联合坦索罗辛治疗良性前列腺增生伴尿路梗阻的临床观察
- Author:
Xiuhua XU
;
Suqiong WU
- Publication Type:Journal Article
- Keywords:
Benign prostatic hyperplasia;
Urinary obstruction;
Compound sabal berry tablet;
Tamsulosin;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(24):3365-3367
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of Compound sabal berry tablet combined with tamsulosin in the treatment of benign prostatic hyperplasia complicated with urinary obstruction. METHODS:86 patients with benign prostatic hyper-plasia complicated with urinary obstruction were randomly divided into control group(43 cases)and observation group(43 cases). Control group orally received 0.2 mg Tamsulosin hydrochloride orally disintegrating sustained-release tablet,once every evening. Observation group additionally received 500 mg Compound sabal berry tablet before a meal,3 times a day. 4-week was regarded as 1 treatment course,and it lasted 3 courses. During the treatment,all patients in the two groups ate light food,avoiding spicy and bland food. The clinical efficacy,TCM symptom scores,interleukin-8 (IL-8),interleukin-10 (IL-10),tumor necrosis factor α(TNF-α),maximum flow rate(Qmax),post-void residual(PVR),the International Prostate Symptom Score(IPSS)scores before and after treatment and the incidence of adverse reactions in the 2 groups were observed. RESULTS:The total effective rate in ob-servation group was significantly higher than control group,the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the TCM symptom scores,Qmax,PVR,IPSS scores,IL-8,IL-10 and TNF-α between 2 groups (P>0.05). After treatment,TCM symptom scores,IPSS scores,IL-8,IL-10,TNF-α and PVR in 2 groups were signifi-cantly lower than before,and observation group was lower than control group,Qmax was significantly higher than before,and obser-vation group was higher than control group,the differences were statistically significant (P<0.05). And there were no severe ad-verse reactions during treatment. CONCLUSIONS:The efficacy of Compound sabal berry tablet combined with tamsulosin is superi-or to tamsulosin alone in the treatment of benign prostatic hyperplasia complicated with urinary obstruction,it can reduce the in-flammatory reactions and residual urine,with good safety.
